Bacteria-visualizing nano-bactericide with anti-inflammation and wound healing properties for in situ NIR
Sen Zhang1, Ailin Wu2, Ancheng Ouyang1
1School of Crystal Materials, State Key laboratory of Crystal Materials, Shandong University, Jinan 250100, China. weiliu@sdu.edu.cn.
Abstract:
Anti-infection and wound healing are critical to the survival of patients with skin burns or postoperative infections, and there is an urgent clinical demand for drugs that combine anti-inflammatory and tissue recovery functions, especially new drugs that can overcome the inherent drug resistance of bacteria to conventional antibiotics. In this work, a phototherapeutic bactericide SiPc-CMCS was constructed by covalently grafting silicon phthalocyanine onto natural carboxymethyl chitosan. SiPc-CMCS ingeniously exhibited combined effects of photodynamic and photothermal therapies with wound healing effects for synergistic anti-inflammation and wound recovery, without the constraints of dosage and drug resistance. Two ROS, namely, O2˙- and 1O2, which belong to type I and type II photodynamic pathways, respectively, were observed, and SiPc-CMCS exhibited a photothermal conversion efficiency of η = 26.80%. In vitro and in vivo studies showed effective NIR photodynamic-photothermal antibacterial effect of SiPc-CMCS against both Gram-positive and Gram-negative bacteria. Furthermore, it realized in situ wound healing and fluorescence bacteria visualizing capability. These data prove that SiPc-CMCS is a potential bacteria-readout-guided NIR phototherapeutic bactericide, which is effective against both aerobic and anaerobic bacterial infections, and it possesses excellent wound-healing capability for treating skin burns and postoperative infections.
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