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Updated: May 13, 2025

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
[Colon polyps-nomenclature, histology, and molecular pathology]
1Pathologisches Institut, Medizinische Fakultät, Ludwig-Maximilians-Universität München, Thalkirchner Straße 36, 80337, München, Deutschland. jens.neumann@med.uni-muenchen.de.
Abstract:
Polyps are macroscopically visible protrusions of the mucosa in hollow organs. In the colon, epithelial neoplasms deriving from the mucosa dominate. These can be classified based on their morphology into classic and serrated adenomas and show different degrees of epithelial dysplasia. The histological subtypes show various molecular alterations and can be assigned to different pathways of carcinogenesis. These must be separated from hamartomatous polyps of the colon mucosa, which can occur sporadically or as part of hereditary syndromes.
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