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Updated: May 13, 2025

Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells
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Author Spotlight: Advancing Reproductive Immunology with a Protocol for the Quantitative Evaluation of Endometrial Immune Cells

Published on: October 13, 2023

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Immune microenvironment and molecular mechanisms in endometrial cancer: implications for resistance and innovative

Yijia Chen1, Lai Jiang1, Lanyue Zhang1

  • 1Clinical Medical College, Southwest Medical University, Luzhou, 646000, China.

Discover Oncology
|April 16, 2025
PubMed

Insights

This review explores endometrial cancer

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Endometrial cancer drug resistance is driven by aberrant signaling pathways.
  • The tumor immune microenvironment critically influences therapeutic outcomes.
  • Hypoxic metabolic reprogramming impacts anticancer therapies.

Purpose of the Study:

  • To systematically review molecular mechanisms of endometrial cancer and drug resistance.
  • To analyze the role of the immune microenvironment in cancer drug resistance.
  • To summarize advances in immunotherapy and individualized therapy for endometrial cancer.

Main Methods:

  • Systematic review of molecular mechanisms.
  • Analysis of signaling pathways and immune microenvironment.
  • Summary of recent therapeutic strategies.

Main Results:

  • Aberrant signaling pathways promote tumor proliferation, anti-apoptosis, and drug resistance.
  • Immune cells, checkpoints, and hypoxia significantly affect drug resistance.
  • Immunotherapy and individualized therapy show promise in advanced endometrial cancer.

Conclusions:

  • Targeting key pathways and modulating the immune microenvironment can overcome drug resistance.
  • Emerging therapeutic strategies aim to improve patient prognosis in endometrial cancer.
Keywords:
Drug resistanceEndometrial cancerImmune checkpoint inhibitorsImmunotherapyMolecular mechanismsPrecision medicineTumor microenvironment

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