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Herpes simplex burn wound infections: epidemiology of a case cluster and responses to acyclovir therapy
Abstract:
Nosocomial transmission of herpes simplex virus (HSV) has been described in intensive care units. A cluster of three patients with HSV wound infections within a 6-week period prompted temporary closure of a burn unit and suggested nosocomial cross infection. However, restriction endonuclease "fingerprint" analysis of the HSV isolates showed them to be genetically and therefore epidemiologically unrelated. This report describes these cases and the use of intravenous acyclovir in the treatment of HSV burn wound infections.
Insights
Nosocomial herpes simplex virus (HSV) wound infections in a burn unit were investigated. Genetic analysis revealed the three cases were unrelated, ruling out cross-infection and highlighting the need for effective HSV treatments.
Area of Science:
- Infectious Diseases
- Virology
- Burn Care
Background:
- Nosocomial herpes simplex virus (HSV) transmission is a concern in intensive care settings.
- A cluster of three HSV wound infections in a burn unit suggested potential nosocomial cross-infection.