Related Experiment Video
Updated: May 14, 2025
09:33
Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
7.4K
Oxidative stress markers during the psychotic transition
Victoria Rambaud1, Ariel Frajerman2, Margot Fournier3
1Université Paris Cité, INSERM U1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
Journal of Psychiatric Research
|April 16, 2025
Summary
Biomarkers for oxidative stress in blood can predict psychosis transition in ultra-high-risk (UHR) individuals. Lower levels of antioxidant peroxiredoxin-4 indicate a reduced risk, while GPx activity and TBARS correlate with symptom severity.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- The ultra-high-risk (UHR) state identifies individuals at risk for psychosis.
- Most UHR individuals do not transition to psychosis, necessitating predictive biomarkers.
- Redox dysregulation is implicated in the pathophysiology of psychotic disorders.
Purpose of the Study:
- To investigate the association between blood oxidative stress markers and psychosis transition in UHR individuals.
- To identify peripheral redox markers that can predict transition to psychosis.
- To explore the relationship between oxidative stress markers and symptom severity.
Main Methods:
- Blood samples were collected from 48 UHR individuals at baseline and 12-month follow-up or at transition.
- Assessed various redox markers including glutathione system, superoxide dismutase, thioredoxin, TBARS, peroxiredoxin-4, MMP9, and sRAGE.
- Analyzed marker evolution in non-converters (UHR-NC) and converters (UHR-C) to psychosis.
Main Results:
- A panel of peripheral redox markers differentiated UHR-C from UHR-NC at baseline.
- Decreased blood peroxiredoxin-4 levels were associated with a lower risk of psychosis transition.
- Glutathione peroxidase (GPx) activity and TBARS levels correlated with later symptom severity.
Conclusions:
- Peripheral oxidative stress biomarkers show potential for monitoring psychosis transition risk in UHR individuals.
- Findings support the development of treatments targeting redox pathways for psychosis prevention and management.
- These biomarkers may aid in early detection and personalized risk assessment.
More Related Videos
Related Concept Videos
01:29Psychological and Sociocultural Causes of Schizophrenia
37
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
37
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
285
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
285
01:27Introduction to Stress and Lifestyle
50
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
50
01:20Psychological Responses to Stress
28
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
28
01:24Mania and Antimanic Drugs: Overview
103
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
103
01:26Aging
29
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
29