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[Dynamics of blood fibronectin level in myocardial infarction]
Insights
Blood fibronectin levels do not aid in diagnosing myocardial infarction. However, rising fibronectin over four weeks may indicate heart repair processes after the event.
Area of Science:
- Cardiology
- Biochemistry
Context:
- Myocardial infarction diagnosis relies on biomarkers like myoglobin, MB creatine kinase, and C-reactive protein.
- Fibronectin's role in myocardial infarction diagnosis requires further elucidation.
Purpose:
- To evaluate the diagnostic utility of blood fibronectin levels in patients with myocardial infarction.
- To compare fibronectin levels with established cardiac biomarkers at various time points.
Summary:
- Fibronectin levels in myocardial infarction patients remained within normal ranges from day 1 to day 28.
- No significant difference in fibronectin was observed between myocardial infarction and unstable angina patients within the first three days.
- Blood fibronectin measurement is not diagnostically significant for myocardial infarction.
Impact:
- The study concludes that fibronectin is not a reliable diagnostic marker for myocardial infarction.
- A progressive increase in fibronectin from day 3 to day 28 suggests its potential role in reflecting myocardial repair activity.
Abstract:
The fibronectin level in the blood of patients with myocardial infarction was measured at varying times from the onset of an angina pectoris attack in order to elucidate the diagnostic importance of blood fibronectin. At the same time these patients were examined over time for the blood content of myoglobin, MB creatine kinase protein and C-reactive protein playing a well-known role in the diagnosis. The blood concentrations of these substances reached the maximal values at different times of myocardial infarction. The mean concentrations of fibronectin in the blood of patients with myocardial infarction ranged within normal starting from the first till the 28th day since the onset of an angina pectoris attack. Moreover, the mean blood fibronectin level in myocardial infarction patients did not differ within the first-third days since the disease onset from that in patients with a clinical picture of unstable angina pectoris which was not accompanied by the development of myocardial infarction. Based on the data obtained it is concluded that measurement of blood fibronectin level does not play any diagnostic role in myocardial infarction. On the other hand, progressive increase in blood fibronectin level throughout 4 weeks starting from the 3d day of the disease and a significantly higher fibronectin content on the 28th day as compared with that on the 3d day is likely to mirror the activity of repair processes occurring in the myocardium.