Related Experiment Video

Updated: May 13, 2025

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
10:25

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

1.7K

Follistatin-like protein 1: Implications for renal disease progression

Yiqi Gao1, Junyi Ren2, Haoyu Peng2

  • 1Tangdu Hospital of the Fourth Military Medical University, Xi'an, Shaanxi, China.

The Journal of Pharmacology and Experimental Therapeutics
|April 16, 2025
PubMed

Insights

Follistatin-like protein 1 (FSTL1) is crucial in kidney diseases, impacting fibrosis and inflammation. Understanding FSTL1

Area of Science:

  • Nephrology
  • Molecular Biology
  • Biochemistry

Background:

  • Renal diseases pose global health challenges with poor prognoses for end-stage conditions.
  • Follistatin-like protein 1 (FSTL1), a secreted glycoprotein, is implicated in cellular processes and immune responses.
  • Existing treatments offer limited improvement for advanced renal failure and kidney tumors.

Purpose of the Study:

  • To review the functions and mechanisms of FSTL1 in kidney pathology.
  • To explore FSTL1's role in the development and progression of renal diseases.
  • To highlight FSTL1's potential as a biomarker and therapeutic target for kidney diseases.

Main Methods:

  • Literature review of studies on FSTL1 and renal pathology.
  • Analysis of FSTL1's involvement in cellular survival, proliferation, differentiation, migration, inflammation, and immune responses.
  • Examination of FSTL1's role in specific renal conditions like fibrosis, inflammation, and ischemia-reperfusion injury.

Main Results:

  • FSTL1 plays a significant role in the onset and progression of various renal diseases.
  • FSTL1 is involved in key pathological processes including renal fibrosis, inflammation, and ischemia-reperfusion injury.
  • FSTL1 exhibits dual roles depending on the specific kidney pathology.

Conclusions:

  • FSTL1 is a critical factor in renal disease pathogenesis.
  • FSTL1 presents potential as a diagnostic biomarker for kidney diseases.
  • Targeting FSTL1 may offer novel therapeutic strategies for managing chronic kidney disease and related complications.
Keywords:
Acute kidney diseaseChronic kidney diseaseFSTL1Renal cell carcinoma

More Related Videos

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis04:57

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

353
Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.2K

Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.2K
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
37
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
1.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
35
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
3.3K