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Integrating pulmonary function testing with cardiopulmonary exercise testing for enhanced stratification in

Robin Willixhofer1,2, Massimo Mapelli1,2, Nikita Baracchini3,4

  • 1Centro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milan, Italy.

Heart (British Cardiac Society)
|April 16, 2025
PubMed

Insights

Pulmonary function testing (PFT) strongly correlates with cardiopulmonary exercise testing (CPET) in hypertrophic cardiomyopathy (HCM). PFT can enhance exercise capacity assessment and patient stratification alongside CPET.

Area of Science:

  • Cardiology
  • Pulmonology
  • Exercise Physiology

Background:

  • Cardiopulmonary exercise testing (CPET) is crucial for evaluating hypertrophic cardiomyopathy (HCM) patients.
  • The utility of pulmonary function testing (PFT) in stratifying HCM patients is not well understood.

Purpose of the Study:

  • To investigate the relationship between PFT and CPET parameters in individuals with HCM.
  • To determine if PFT can refine patient stratification in HCM.

Main Methods:

  • A prospective, two-center study involving 102 stable HCM patients.
  • Utilized Spearman's correlation and multiple linear regression to analyze PFT (FVC, FEV1) and CPET variables.
  • Adjusted for potential confounding factors in the analysis.

Main Results:

  • HCM patients demonstrated preserved lung function (mean FVC: 90.7%, FEV1: 92.5%).
  • Significant correlations were found between PFT metrics and CPET variables, including peak oxygen consumption (VO2) and peak ventilation.
  • Regression analysis confirmed independent associations between PFT and CPET performance (p<0.001).

Conclusions:

  • Pulmonary function testing metrics show a strong correlation with CPET parameters in HCM.
  • PFT may serve as a valuable adjunct to CPET for a more thorough assessment of exercise capacity.
  • PFT could improve patient stratification in hypertrophic cardiomyopathy.
Abstract

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