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Unlocking the secrets: Exploring the connection between HPV and bladder cancer in Pakistan
Hafsa Yousaf1, Aneela Javed1, Nuzhat Sultana2
1Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), H-12 Sector, Islamabad - 44000, Pakistan.
Urologic Oncology
|April 16, 2025
Summary
High-risk Human Papillomavirus (HPV) genotypes were detected in 15.9% of bladder cancer cases in Pakistan. This study highlights HPV as a potential risk factor for bladder cancer, particularly in low- and middle-income countries.
Area of Science:
- Oncology
- Virology
- Epidemiology
Background:
- Human Papillomavirus (HPV) is linked to anogenital cancers.
- Its role in urologic carcinomas is under-researched, especially in Pakistan.
- This study addresses a critical gap in understanding HPV's role in bladder cancer etiology.
Purpose of the Study:
- To investigate the association between high-risk HPV genotypes and bladder cancer.
- To determine the prevalence and genotype distribution of HPV in bladder cancer patients in Pakistan.
Main Methods:
- Bladder biopsies from 63 cancer patients were analyzed.
- DNA was extracted for HPV detection using L1 consensus primers.
- HPV genotyping for HPV16 and HPV18 was performed using PCR.
Main Results:
- 15.9% of bladder cancer cases were HPV-positive.
- HPV16 and HPV18 were the most common genotypes found.
- HPV-positive cancers were predominantly low-grade invasive urothelial carcinoma.
Conclusions:
- HPV is associated with bladder cancer incidence in Pakistan.
- HPV represents a significant risk factor for preventable cancers in LMICs.
- Further research is needed to understand HPV's full impact on urologic malignancies.
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