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Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
The correlation between insulin-like growth factor 1 and left ventricular mass index in obese children
Wanxia Niu1, Chen Li2, Zhaorui Wang3
1Department of Pediatrics, Shandong Public Health Clinical Center, Shandong University, Jinan, 250013, China.
Insights
Obese children with lower Insulin-like Growth Factor 1 (IGF-1) levels show increased Left Ventricular Mass Index (LVMI), a cardiovascular risk marker. Monitoring IGF-1 may aid early detection of cardiovascular issues in this population.
Area of Science:
- Pediatric Endocrinology
- Cardiovascular Health
- Metabolic Disorders
Background:
- Low Insulin-like Growth Factor 1 (IGF-1) is linked to cardiovascular disease.
- Obesity in children is associated with reduced IGF-1 levels.
- The relationship between IGF-1 and Left Ventricular Mass Index (LVMI) in obese children is not well-established.
Purpose of the Study:
- To investigate the correlation between IGF-1 levels and LVMI in obese children.
- To assess cardiovascular risk factors in obese pediatric populations.
Main Methods:
- 104 obese children and 61 healthy controls were studied.
- Measurements included anthropometrics, IGF-1, cardiovascular metabolic factors, and echocardiography to determine LVMI.
- Statistical analyses controlled for confounding factors like cholesterol, triglycerides, and uric acid.
Main Results:
- Obese children had higher LVMI and lower IGF-1 standard deviation scores (SDS) than controls.
- A significant negative correlation was found between IGF-1 SDS and LVMI (β = -0.161, p=0.046).
- Insulin resistance (HOMA-IR) showed a positive correlation with LVMI (β = 0.241, p=0.007).
Conclusions:
- IGF-1 and LVMI are independently negatively correlated in obese children.
- Monitoring IGF-1 may help identify cardiovascular risks in obese children.
- Early intervention strategies can be developed based on these findings.
Objective:
Low levels of Insulin-like Growth Factor 1 (IGF-1) are known risk factors for cardiovascular diseases. Left Ventricular Mass Index (LVMI) serves as an early predictor of adverse cardiovascular events. Obese children have relatively low concentrations of IGF-1 in their blood. To date, there is no research on whether there is a correlation between IGF-1 levels and LVMI in obese children. This study aims to investigate the potential correlation between IGF-1 and LVMI in obese children at a single center.
Methods:
A total of 104 obese children were selected as the case group, while 61 healthy children undergoing physical examinations served as the normal control group. Anthropometric measurements, assessments of IGF-1, and cardiovascular metabolic factors were conducted. Echocardiographic examinations were also performed to calculate the LVMI.
Results:
Compared to the control group, the obese group had significantly higher LVMI and significantly lower standard deviation scores for Insulin-like Growth Factor 1 (IGF-1 SDS). After controlling for confounding factors including total cholesterol (TC), triglycerides (TG), and uric acid (UA), there was a significant linear negative correlation between IGF-1 SDS and LVMI, and a significant linear positive correlation between homeostasis model of assessment for insulin resistance (HOMA-IR) and LVMI. Each unit increase in IGF-1 SDS resulted in a 16.1% decrease in LVMI (β = -0.161; p = 0.046), and each unit increase in HOMA-IR resulted in a 24.1% increase in LVMI (β = 0.241; p = 0.007).
Conclusion:
IGF-1 and LVMI exhibit an independent negative correlation. Monitoring IGF-1 levels might provide valuable insights into the cardiovascular health of obese children, facilitating early identification and management of cardiovascular risk factors.
Clinical Trial Number:
Not applicable.
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