Analysis glycemic variability in pregnant women with various type of hyperglycemia

The study primarily aims to compare alterations in the daily patterns of glucose fluctuations across individuals with different kinds of diabetes in pregnancy and secondly investigate influencing factors that may react with glucose variations.

We conducted a retrospective cohort study of 776 pregnant women in Shanghai General Hospital. We grouped participants who were exposed to gestational hyperglycemia into 5 sub-groups [Type 1 diabetes (T1DM), Type 2 diabetes (T2DM), Overt diabetes, Gestational diabetes (GDMA1 and GDMA2). Demographic variables and GV parameters were compared among 5 groups through ANOVA-test and Chi-square test. We estimated odd ratios (ORs) for the association between glucose coefficient of variation (CV) and possible influencing variables.

A final total of 776 pregnant women were analyzed. The proportion of pregnant women with pre-gestational diabetes was 31.83% (T1DM: 3.35%,T2DM: 28.48%), ODM 26.68%, and GDM was 41.49% (GDMA1:18.04%, GDMA2: 23.45%). T1DM group performed greatest glucose fluctuations with a CV value 35.02% whereas the number in all the other groups was no more than 22.82% (ODM group). In terms of achieving glycemic control target, only 57.70% participants hit the goal while all the other groups achieved the standard with at least a percentage of 94.20% (ODM group). Other parameters (GMI < 6.0%, GA < 15.70% and HbA1c < 6.0%) showed similar trends in each group. On multivariate logistic regression analysis of possible factors influencing CV, only body mass index (BMI) (OR: 0.754, 95% CI: 0.585-0.971; P = 0.029), HOMA- β (OR:0.969, 95%CI: 0.959-0.976; P = 0.037) and fasting plasma glucose (FPG) (OR: 1.832, 95% CI: 1.170-2.870; P = 0.008) reached statistical significance.

Pregnant women with type 1 or type 2 diabetes exhibit significantly greater glycemic variability compared to those with gestational diabetes, with the ODM group showing intermediate variability, and BMI, HOMA-β, and FPG identified as independent risk factors for unstable glucose variability.