Related Experiment Video
Updated: May 11, 2025
A Coregistered Ultrasound and Photoacoustic Imaging Protocol for the Transvaginal Imaging of Ovarian Lesions
Published on: March 3, 2023
Multiple pulmonary mucinous cystadenoma with Ovarian-like stroma: a case report
Lei Wang1, Xieraili Wumener2, Wenting Huang3
1Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, China.
Background:
Pulmonary mucinous cystadenoma with ovarian-like stroma has rarely been reported. To the best of our knowledge, only two prior cases have been reported to date.
Case Presentation:
A 47-year-old female underwent an 18F-fluorodeoxyglucose(FDG) positron emission tomography/computed tomography(PET/CT) scan, revealig multiple solid and cystic nodules with mild FDG uptake in both lungs. The tumor exhibited an adenoid or papillary structure, covered by monolayer mucous columnar epithelium and pseudostratified ciliated columnar epithelium, with abundant mesenchymal cells. Nuclei were oval, fusiform, or polygonal, resembling ovarian-like stroma, and showed mild nuclear atypia without atypical mitoses. Immunohistochemical analysis indicated: CK (epithelial cell +), P63 (epithelial basal cells +), CK7 (epithelial cell +), CK20 (-), TTF-1 (epithelial cell +), napsin A (partial epithelial cell +), α-inhibin (-), S100 (-), SMA (-), EMA (epithelial cell +), CEA (-), WT-1 (mesenchymal cells +), ER (mesenchymal cells +), P16 (partial mesenchymal cells +), CD10 (mesenchymal cells +), and Ki-67 (2% +).
Conclusion:
Pulmonary mucinous cystadenoma with ovarian-like stroma is rare, and its pathological nature and classification are not yet fully understood.
