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Quantitative in vivo assessment of intraocular lens calcification: correlation between OCT opacity and straylight
Lars H B Mackenbrock1, Grzegorz Łabuz, Nikola Henningsen
1From the David J Apple Center for Vision Research, Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany (Mackenbrock, Łabuz, Henningsen, Auffarth, Khoramnia, Yildirim); University Hospital Carl Gustav Carus Dresden, Department of Ophthalmology, Dresden, Germany (Mackenbrock, Khoramnia).
Purpose:
To quantitatively assess intraocular lens (IOL) calcification using anterior segment optical coherence tomography (AS-OCT) and correlate findings with straylight measurements in patients with homogenous IOL calcification.
Setting:
Department of Ophthalmology, Heidelberg University Hospital, Heidelberg, Germany.
Design:
Prospective, observational clinical study.
Methods:
Healthy patients with homogenous IOL calcification underwent AS-OCT imaging with the ANTERION, with IOL opacity being automatically quantified using a custom image-analysis script. Straylight was assessed using the C-Quant straylight meter. Correlation between IOL opacity and straylight was analyzed using Spearman ρ coefficient.
Results:
35 eyes of 35 patients (mean age 72.9 ± 7.8 years) were included. Mean IOL opacity was 69.15 ± 13.55 pixel intensity units (PIUs), and mean straylight was 2.24 ± 0.38 log(s). A statistically significant correlation was found between IOL opacity and straylight with ρ = 0.494, P = .003. After the linear regression model was established: straylight = 0.0569 × OCT opacity [log(s)] - 1.69 with R2 = 0.244. Of the 35 eyes, 17 underwent IOL exchange surgery, with a mean IOL opacity of 75.69 ± 7.58 PIU and a mean straylight of 2.33 ± 0.30 log(s).
Conclusions:
AS-OCT can quantitatively assess IOL calcification in vivo, with results correlating significantly with straylight measurements. This technique may serve as a valuable diagnostic tool for evaluating IOL opacification and assist in surgical decision-making, particularly in borderline cases.
