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Plasma Lipidomics Profiling of Developmental Dysplasia of the Hip in Tibet Plateau

Xiaogang Li1, Jiamei Ji2, Ping Li3

  • 1Biobank Facility, National Infrastructures for Translational Medicine, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing China.

Health Care Science
|April 17, 2025
PubMed

Insights

Lipidomics analysis revealed distinct differences in plasma lipid profiles of infants with developmental dysplasia of the hip (DDH). Specific triacylglycerol (TAG) and phosphatidylethanolamine (PE) signatures may aid in DDH diagnosis.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Metabolomics

Background:

  • Developmental dysplasia of the hip (DDH) is a common pediatric condition with varied causes.
  • Higher incidence rates of DDH are reported in populations on the Tibet plateau.
  • This study investigated lipidomics profiles in relation to DDH.

Purpose of the Study:

  • To identify specific lipidomics signatures associated with developmental dysplasia of the hip (DDH) in infants.
  • To explore the potential of lipid profiles as diagnostic markers for DDH.

Main Methods:

  • Plasma samples were collected from 50 infants (25 with DDH, 25 healthy controls).
  • An untargeted lipidomics profiling approach was utilized.
  • Comprehensive clinical data were gathered for each participant.

Main Results:

  • Significant differences in lipidomics profiles were observed between DDH patients and controls.
  • Key differential metabolites included various triacylglycerols (TAGs) and phosphatidylethanolamines (PEs).
  • TAG(17:0/18:1/20:1) and TAG(17:0/17:0/17:0) were among the most significant altered lipids.

Conclusions:

  • Infants with DDH exhibit distinct alterations in their plasma lipidomics profiles.
  • This is the first study to report lipidomics signatures in DDH patients.
  • Combined analysis of TAG(17:0/18:1/20:1) and TAG(17:0/17:0/17:0) shows potential as a diagnostic tool for DDH.
Abstract

Keywords:
developmental dysplasia of the hipdiagnosislipidomicspediatric orthopedicphosphatidylethanolaminetriacylglycerols

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