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Updated: Jul 24, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Meta-analysis of animal experiments on osteogenic effects of trace element doped calcium phosphate ceramic/PLGA
Hongwei He1,2, Meng Zhong1,2, Panxianzhi Ni1,2
1National Engineering Research Center for Biomaterials, 12530 Sichuan University , Chengdu, Sichuan, China.
Objectives:
Investigate the impact of the components in element-doped calcium phosphate ceramic/PLGA composites on bone repair outcomes in animal experiments.
Methods:
Computer search of CNKI, Wanfang, Pub Med, Web of science, and EMbase databases to collect related randomized controlled animal experimental studies. Using the SYRCLE Animal Experimental Bias Risk Assessment form to evaluate research quality. The outcome measures were statistically analyzed using the Rev Man 5.4 software.
Results:
Included 11 randomized controlled animal studies. Meta-analysis showed that: (1) Element doping can promote the proliferation of osteoblasts in vitro. (2) Element doping can increase the activity of ALP in cells. (3) Element doping can increase bone volume fraction. (4) Element doping can increase trabecular number.
Conclusions:
Trace element doping has been found to enhance the osteogenic effect of the composite material. The type of calcium phosphate ceramics may be a significant source of heterogeneity that influences the effectiveness of bone repair in vivo.
