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Tricin Delays Aging and Enhances Muscle Function via Activating AMPK-Mediated Autophagy in Diverse Model Organisms

Yun-Fei Zhu1, Xing-Yue Zhou1, Cai Lan1

  • 1Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, China.

Journal of Agricultural and Food Chemistry
|April 17, 2025
PubMed

Insights

Tricin, a flavonoid from grains, combats aging by activating AMPK-mediated autophagy. This natural compound delays cellular aging and improves healthspan in model organisms and mice.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Biochemistry

Background:

  • Aging causes cellular and organ dysfunction, necessitating novel therapeutic strategies.
  • Flavonoids, like tricin found in grains, are explored for their potential health benefits.
  • Cellular senescence and age-related decline impact muscle performance and overall health.

Purpose of the Study:

  • To investigate the antiaging properties of tricin in various biological models.
  • To elucidate the molecular mechanisms underlying tricin's effects on cellular aging.
  • To evaluate tricin's efficacy in ameliorating age-related phenotypes in vivo.

Main Methods:

  • Tricin's effects were tested on human fibroblasts, Caenorhabditis elegans (C. elegans), and mice.
  • Senescence markers (SA-β-gal, p16, p21, SASP factors) were analyzed in vitro and in vivo.
  • The AMPK-mTOR-p70S6K signaling pathway and autophagy were investigated to understand tricin's mechanism.

Main Results:

  • Tricin alleviated senescence in human fibroblasts and improved lifespan and mobility in C. elegans.
  • The compound activates the AMPK-mTOR-p70S6K pathway, promoting autophagy and delaying cellular aging.
  • In aging mice, tricin enhanced muscle function and reduced senescence markers.

Conclusions:

  • Tricin demonstrates significant antiaging potential by delaying cellular senescence.
  • Activation of AMPK-mediated autophagy is a key mechanism for tricin's antiaging effects.
  • Tricin is a promising natural therapeutic candidate for combating age-related decline.
Keywords:
AMPKantiagingautophagymuscle functiontricin

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