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Kinetically Arrested SERS-Active Aggregates for Biosensing.

Natalie S Potter1, Kamil Sokołowski1, Renata Lang Sala1

  • 1Melville Laboratory for Polymer Synthesis, Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 17, 2025
PubMed
Summary
This summary is machine-generated.

New gold nanoparticle (AuNP) assemblies with cucurbit[7]uril (CB[7]) and thiolated poly(ethylene glycol) (PEG-SH) show enhanced stability and sensitivity for non-invasive biosensing in biofluids.

Keywords:
biosensorsdisassemblykinetically arrested aggregatesself‐assemblysurface‐enhanced Raman spectroscopy (SERS)

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Biosensors are needed for long-term, non-invasive monitoring of low analyte concentrations in biofluids for healthcare.
  • Biofluid complexity challenges biosensor sensing and stability.
  • Surface Enhanced Raman Spectroscopy (SERS) offers sensitive, real-time, non-destructive detection in complex media.

Purpose of the Study:

  • To develop stable, tuneable SERS-active gold nanoparticle (AuNP) assemblies for biofluid analysis.
  • To overcome the precipitation issue of AuNP:CB[7] aggregates.
  • To demonstrate low-concentration detection of analytes in biofluids.

Main Methods:

  • Fabrication of kinetically trapped metastable AuNP:CB[7]:PEG aggregates using thiolated poly(ethylene glycol) (PEG-SH).
  • Tuning SERS activity via modification of PEG chain length and grafting density.
  • Detection of a Raman reporter and a bioanalyte in various biofluids.

Main Results:

  • AuNP:CB[7]:PEG aggregates exhibit maintained SERS activity and improved stability compared to AuNP:CB[7] aggregates.
  • The aggregates show tunable sensitivity based on PEG modification.
  • Low concentration detection of analytes in biofluids was demonstrated.

Conclusions:

  • Kinetically trapped metastable AuNP:CB[7]:PEG aggregates offer a stable and tuneable platform for SERS-based biosensing.
  • These aggregates show potential for non-invasive in vivo long-term monitoring and customized biosensing applications.