Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HDAC inhibitors reverse YAP-driven immune resistance in NSCLC: mechanistic and translational evidence.

Journal for immunotherapy of cancer·2026
Same author

Correction: ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC Class I.

Cell death & disease·2026
Same author

The Mechanism of Oxidative Stress in Pulmonary Fibrosis and Research Progress.

Antioxidants (Basel, Switzerland)·2026
Same author

Nintedanib enhances tumor cell radiosensitivity by promoting ferroptosis and modulating the ATF4/SLC7A11/GSH axis.

Cancer biology & medicine·2025
Same author

Molecular mechanisms underlying the abscopal effect induced by radiotherapy and its synergistic translational potential with immunotherapy.

Therapeutic advances in medical oncology·2025
Same author

FAM111B Overexpression and Immune Cell Infiltration: Implications for Ovarian Cancer Immunotherapy.

Biomedicines·2025

Related Experiment Video

Updated: Jun 24, 2026

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
05:18

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

Published on: June 9, 2020

11.0K

Unveiling FAM111B: A Pan-Cancer Biomarker for DNA Repair and Immune Infiltration.

Fang Wei1, Wanying Li1, Ting Zhou1

  • 1Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

International Journal of Molecular Sciences
|April 17, 2025
PubMed
Summary

FAM111B expression is elevated in most cancers, correlating with poor prognosis and DNA repair pathways. This suggests FAM111B is a potential pan-cancer biomarker for DNA repair and T-cell infiltration.

Keywords:
DNA repairFAM111Bhomologous recombination repairpan-cancer

More Related Videos

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

10.0K
Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
04:20

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

Published on: February 9, 2024

840

Related Experiment Videos

Last Updated: Jun 24, 2026

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
05:18

Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells

Published on: June 9, 2020

11.0K
Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

10.0K
Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
04:20

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

Published on: February 9, 2024

840

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genomics

Background:

  • FAM111B is implicated in cancer progression, but its pan-cancer role is unclear.
  • Understanding FAM111B's function is crucial for developing new cancer therapies.

Purpose of the Study:

  • To systematically investigate the pan-cancer implications of FAM111B.
  • To explore the oncogenic potential and molecular mechanisms of FAM111B in various cancers.

Main Methods:

  • Utilized TCGA and GTEx data with GEPIA2, TIMER2.0, and STRING tools for expression analysis.
  • Performed pathway enrichment analyses (GO, KEGG, Reactome, WikiPathways).
  • Validated findings using multiplex immunofluorescence, microarray assays, and protein transcriptomics.

Main Results:

  • FAM111B expression is elevated across most cancer types, linked to poorer prognostic outcomes.
  • FAM111B expression positively correlates with DNA homologous recombination repair genes.
  • FAM111B correlates with Th2 CD4+ T-cell infiltration, validated in pancreatic and ovarian cancers.

Conclusions:

  • FAM111B acts as a significant pan-cancer oncogene.
  • FAM111B serves as a potential biomarker for DNA repair pathways and Th2 CD4+ T-cell infiltration in human malignancies.