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Updated: May 11, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next-Generation Sequencing in Oncology-A Guiding Compass for Targeted Therapy and Emerging Applications

Laurenția Nicoleta Galeș1,2, Mihai-Andrei Păun1, Ioana Butnariu1,3

  • 1"Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

International Journal of Molecular Sciences
|April 17, 2025
PubMed

Insights

Multigene sequencing, like next-generation sequencing (NGS), identifies genetic mutations for targeted cancer therapies. This molecular guidance improves treatment decisions and patient outcomes in precision oncology.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Multigene sequencing technologies are crucial for advancing precision oncology.
  • Identifying actionable genetic alterations is key to developing effective targeted therapies.

Purpose of the Study:

  • To highlight the pivotal role of next-generation sequencing (NGS) in modern oncology.
  • To emphasize the importance of molecular profiling in guiding cancer treatment decisions.

Main Methods:

  • This review synthesizes current knowledge on multigene sequencing in oncology.
  • Focuses on the application of NGS for identifying genetic mutations and guiding therapy.

Main Results:

  • NGS enables the identification of a wide range of actionable alterations.
  • Molecular profiling acts as a compass for navigating complex genetic landscapes in cancer.

Conclusions:

  • NGS is indispensable for targeted therapy and precision oncology.
  • Molecular guidance through NGS significantly improves clinical outcomes for cancer patients.
Keywords:
next-generation sequencingprecision oncologytargeted therapy

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