Photocatalytic Synthesis of Diaryl Amides via Direct Coupling of Methyl Arenes and Nitroarenes
Robin Prakash Sirvin Rajan1, Chae Eun Hong1, Kyungho Park2
1Department of Chemistry, Chonnam National University, Gwangju 61186, Republic of Korea.
Abstract:
A direct and effective method for synthesizing diaryl amides has been developed through the photocatalytic coupling of methyl and nitroarenes. This method employs FeCl3 as a redox-active photocatalyst under mild conditions to enable selective benzylic C-H activation and concurrent nitro group reduction, eliminating the necessity for pre-functionalization. This method exhibits a broad substrate scope, high functional group tolerance, and improved atom economy, offering a sustainable and practical alternative to amide bond formation.
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