The Clinical Utility and Plausibility of Oxidative and Antioxidant Variables in Chronic and End-Stage Kidney Disease: A Review of the Literature
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View abstract on PubMed
Summary
This summary is machine-generated.Oxidative stress (OS) worsens chronic kidney disease (CKD) and end-stage renal disease (ESRD) outcomes. This review details key biomarkers for diagnosing and managing OS in CKD patients.
Area Of Science
- Nephrology
- Biochemistry
- Oxidative Stress Research
Background
- Oxidative stress (OS) results from an imbalance between reactive oxygen species (ROS) production and detoxification.
- In chronic kidney disease (CKD), OS accelerates kidney function decline and disease progression.
- OS is significantly elevated in end-stage kidney disease (ESKD) patients on dialysis, linked to poor clinical outcomes.
Purpose Of The Study
- To review clinically relevant biomarkers of OS in CKD patients.
- To elucidate the roles of specific pro-oxidants and antioxidants in CKD.
- To provide a clearer understanding of OS in CKD for improved patient management.
Main Methods
- Literature review of existing data on OS biomarkers in CKD.
- Focus on clinically relevant and extensively studied pro-oxidants and antioxidants.
- Synthesis of information on biomarkers such as oxidized albumin, MDA, SOD, and catalase.
Main Results
- Identified key pro-oxidant biomarkers: oxidized albumin, advanced oxidation protein products, xanthine oxidase/dehydrogenase, nitrite/nitrate, and malondialdehyde.
- Highlighted important antioxidant biomarkers: superoxide dismutase, catalase, vitamin E, total antioxidant capacity, and N-acetylcysteine.
- Demonstrated the clinical relevance of these biomarkers in CKD progression and outcomes.
Conclusions
- Oxidative stress is a critical factor in CKD progression and associated complications.
- A clear understanding of OS biomarkers is essential for diagnosis and treatment strategies.
- Further research and consensus on OS management in CKD patients are needed.
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