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Updated: May 11, 2025

Manufacturing Abdominal Aorta Hydrogel Tissue-Mimicking Phantoms for Ultrasound Elastography Validation

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Published on: September 19, 2018

RAGE deficiency ameliorates abdominal aortic aneurysm progression.

Cong Bi¹, Bingqi Liu¹, Peixian Gao¹

¹Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]

|April 17, 2025

Summary

Receptor for advanced glycation end products (RAGE) deficiency reduces abdominal aortic aneurysm (AAA) progression by decreasing inflammation and altering macrophage polarization. This suggests RAGE is a potential therapeutic target for AAA.

Keywords:

Abdominal aortic aneurysms Inflammation Macrophage polarization Receptor for advanced glycation end products

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Published on: February 23, 2020

Area of Science:

Vascular Biology
Immunology
Molecular Medicine

Background:

Abdominal aortic aneurysm (AAA) involves inflammation and arterial wall degradation.
The receptor for advanced glycation end products (RAGE) influences inflammatory pathways, but its role in AAA is not fully understood.

Purpose of the Study:

To investigate RAGE's role in AAA pathogenesis.
To examine RAGE expression in human and mouse AAA tissues.
To determine the effects of RAGE deficiency on AAA progression, macrophage polarization, and inflammation.

Main Methods:

Analyzed RAGE expression in human AAA and mouse models (porcine pancreatic elastase-induced).
Utilized Western blotting, immunohistochemistry, and immunofluorescence.
Assessed AAA progression in RAGE-deficient mice and studied macrophage polarization and NF-κB signaling in vitro.

Main Results:

Elevated RAGE expression observed in AAA tissues, especially in macrophages.
RAGE deficiency reduced AAA incidence, mortality, and aortic dilation.
Preserved aortic structure, decreased inflammatory infiltration, and suppressed M1 macrophage polarization and pro-inflammatory cytokines via NF-κB pathway.

Conclusions:

RAGE deficiency mitigates AAA progression by modulating macrophage polarization and reducing inflammation through the NF-κB pathway.
RAGE emerges as a potential therapeutic target for abdominal aortic aneurysm.