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Related Concept Videos

Metastasis02:30

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Related Experiment Video

Updated: May 11, 2025

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
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Risk Factors for Lymph Node Metastasis in Stage pT1 Invasive Lung Adenocarcinoma.

Shou-Kang Li1, Nai-Cheng Song1, Quan Liu1

  • 1Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Current Medical Science
|April 17, 2025
PubMed
Summary

High solid components and wild-type EGFR are key risk factors for lymph node metastasis in early-stage lung adenocarcinoma. This finding aids in selecting appropriate surgical options for patients with invasive lung cancer.

Keywords:
Epidermal growth factor receptorGround-glass nodulesLung adenocarcinomaLung segmentectomyLymph node metastasis

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Area of Science:

  • Oncology
  • Thoracic Surgery
  • Pathology

Background:

  • Lung adenocarcinoma is a leading cause of cancer mortality.
  • Accurate staging is crucial for effective treatment planning.
  • Identifying risk factors for lymph node metastasis (LNM) in early-stage disease is essential for surgical decision-making.

Purpose of the Study:

  • To identify risk factors for lymph node metastasis (LNM) in patients with stage pT1 lung adenocarcinoma.
  • To inform surgical strategy selection for early-stage lung cancer.

Main Methods:

  • Retrospective analysis of 294 patients with stage pT1 invasive lung adenocarcinoma.
  • Comparison of patients with and without mediastinal or hilar LNM.
  • Analysis of tumor imaging, pathological features, and gene mutations.
  • Logistic regression and Boruta/least absolute shrinkage and selection operator (LASSO) analysis for risk factor identification.

Main Results:

  • 15.3% of patients had positive lymph nodes.
  • High percentage of solid components and wild-type epidermal growth factor receptor (EGFR) were identified as significant risk factors for LNM.
  • A predictive nomogram incorporating consolidation tumor ratio, tumor size, micropapillary patterns, and EGFR achieved high accuracy (AUC >92%) in both derivation and validation cohorts.

Conclusions:

  • A high proportion of solid components and wild-type EGFR are significant predictors of LNM in pT1 lung adenocarcinoma.
  • These findings suggest a need for careful evaluation and selection of lung segmentectomy in such cases.
  • The developed nomogram can aid in risk stratification and surgical planning for early-stage lung cancer.