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Updated: May 11, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
One-Pot Stepwise Dechalcogenization of Trisulfides to Unsymmetrical Dialkyl Thioethers
Jiuwen Xu1, Ying Chen1, Weidong Rao2
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, P. R. China.
Abstract:
The construction of C-S bonds has garnered significant interest due to the ubiquitous presence of organosulfur compounds in natural products and bioactive molecules. Herein, we report a one-pot, stepwise desulfuration strategy employing trisulfides as precursors for the synthesis of unsymmetrical dialkylthioethers. Our study demonstrates that copper powder facilitates the conversion of trisulfides into disulfides, which subsequently undergo a nickel-catalyzed reductive coupling to afford the desired products. This approach provides a practical, odorless, and broadly applicable method for the synthesis of unsymmetrical dialkylthioethers.
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