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Related Experiment Video

Updated: Jun 11, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

Published on: January 13, 2013

Promising Prodiginins Biological Activities.

María F Ladetto^1,2, Melisa E Gantner³, Boris E Rodenak-Kladniew⁴

¹Laboratorio de Nanobiomateriales, CINDEFI-Departamento de Química, Facultad de Ciencias Exactas, CONICET-UNLP (CCT La Plata), La Plata, Buenos Aires, Argentina.

Chemistry & Biodiversity

|April 17, 2025

Summary

This summary is machine-generated.

Prodiginins, natural compounds from microbes, show promise for treating infections like SARS-CoV-2. Their interaction with cell membranes suggests potential therapeutic applications.

Keywords:

antiviral biocide activities drug delivery models in silico studies nanodevices prodiginins prodigiosin

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Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

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Last Updated: Jun 11, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli

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Published on: January 13, 2013

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

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Published on: January 13, 2017

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

Area of Science:

Microbiology
Medicinal Chemistry
Pharmacology

Background:

Prodiginins are a diverse family of microbial compounds, with prodigiosin being a well-studied example.
These compounds exhibit a wide range of biological activities, including antimicrobial, antiviral, and antiproliferative effects.
Microbial metabolites are increasingly recognized for their therapeutic potential.

Purpose of the Study:

To review the physicochemical and biological properties of prodiginins.
To analyze the mechanisms of action of prodiginins for treating microbial diseases.
To explore the potential of prodiginins in combating SARS-CoV-2 and associated opportunistic infections.

Main Methods:

Literature review and analysis of existing studies on prodiginins.
Examination of prodigiosin as a model molecule.
In silico studies, including molecular dynamics simulations.
Analysis of interactions with cellular membranes and drug delivery systems.
Review of toxicological data.

Main Results:

Prodiginins possess significant antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
Prodigiosin's interaction with lipids in cellular membranes was elucidated.
In silico studies confirmed the potential for therapeutic applications.
Toxicological data and drug delivery considerations were analyzed.

Conclusions:

The prodigiosin motif's interaction with lipids highlights a novel therapeutic avenue.
Prodiginins demonstrate considerable potential for treating microbial diseases, including COVID-19 related infections.
Further research into prodiginins could lead to new antimicrobial and antiviral therapies.