[Importance of the cyclophosphane administration regimen for its immunomodulating and antitumor effect in...

Cytological examinations and evaluation of the proliferative response of lymph node lymphocytes to T- and B-cell mitogens in vivo were carried out to identify the immunomodulating effect of cyclophosphamide (CP) versus the scheme of treatment. Using the system of adoptive transfer of splenic lymphocytes from experimental animals to intact syngeneic recipients, it was found that the scheme-dependent differentiated effects of CP on the antigen-specific tumor-associated and nonspecific suppressive activity of spleen cells provides an important pathway of CP action on the organism. A relationship between CP immunomodulating effects and lymphocyte antitumor activity was demonstrated in experiments using diffusion chambers.