Engineering multifunctional high-entropy oxide nanozymes for robust marine antifouling

High-performance interfacial antifouling coatings are crucial for sustainable marine resource utilization. This work reports a novel high-entropy oxide (HEO) nanozyme, CrMnFeNiCuOX nanoparticles, where the synergistic interplay of polymetallic cations and defect engineering yield remarkable multi-enzyme mimetic activity combined with a photothermal conversion efficiency of 40.06%. Under simulated solar irradiation, the HEO nanozyme exhibited complete (100%) bactericidal activity against both Escherichia coli and Staphylococcus aureus, and effectively suppresses biofilm formation in a simulated marine environment. Mechanistic investigations demonstrated that the HEO nanozyme exhibits a tailored electronic structure and adsorption properties, enabling disruption of bacterial membrane integrity, perturbation of intracellular redox homeostasis, and suppression of quorum sensing signaling. This multifaceted approach offers a promising strategy for developing durable and environmentally friendly antifouling coatings for diverse marine applications.