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[Invasive aspergillosis in patients who died from acute leukemia]
Abstract:
The necropsy material with acute leukosis (166 deceased) was studied in order to establish the incidence of invasive aspergillosis. It was established in 16 of the deceased (9,64%): aspergillosis pneumonia--in 5 cases, aspergillosis sepsis--in II, with invasion of lungs, brain, spleen, liver, myocardium and other organs. Clinically aspergillosis was not distinguished. Continuous septic temperature, not influenced by antibiotic therapy should draw the attention to the presence of aspergillosis. The factors, preconditioning aspergillosis infection are stressed upon: immune-suppressive treatment in acute leukosis, granulocytopenia, continuous preceding antibiotic therapy, etc. The difficulties in the clinical differentiation of the infection are emphasized. With a view to the high incidence and lethality of aspergillosis in acute leukosis, the introduction of modern diagnostic methods and treatment are underlined to be necessary.
Insights
Invasive aspergillosis occurred in 9.64% of patients with acute leukosis, often presenting as sepsis or pneumonia. Early diagnosis and treatment are crucial due to high mortality.
Area of Science:
- Medical Mycology
- Hematology
- Infectious Diseases
Context:
- Acute leukosis patients are immunocompromised, increasing susceptibility to opportunistic infections.
- Necropsy data from 166 deceased patients with acute leukosis were analyzed.
- Invasive aspergillosis is a significant, often fatal, complication in this patient group.
Purpose:
- To determine the incidence of invasive aspergillosis in patients with acute leukosis.
- To identify clinical and pathological features of aspergillosis in this cohort.
- To highlight diagnostic challenges and emphasize the need for improved management strategies.
Summary:
- Invasive aspergillosis was identified in 16 of 166 (9.64%) deceased acute leukosis patients.
- Manifestations included aspergillosis pneumonia (5 cases) and aspergillosis sepsis (11 cases), with widespread organ involvement.
- Clinical diagnosis was challenging, with persistent septic fever unresponsive to antibiotics being a potential indicator.
Impact:
- The study underscores the high incidence and lethality of invasive aspergillosis in acute leukosis.
- It highlights difficulties in clinical differentiation, necessitating advanced diagnostic methods.
- Recommendations include implementing modern diagnostic and therapeutic approaches to improve patient outcomes.