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Published on: August 15, 2019
Structural impact of GSR and LRP8 gene polymorphisms on protein function and their role in racing performance of
Hanna Kulig1, Daniel Polasik1, Radosław Drozd2
1Department of Genetics, West Pomeranian University of Technology, Aleja Piastów 45, 70-311 Szczecin, Poland.
Abstract:
Glutathione reductase (GSR) plays a critical role in the prevention of oxidative damage within the cell. Apolipoprotein E receptor 2 (LRP8) participates in a pathway that modulates synaptic plasticity events crucial for learning and memory. The above aspects are very important when homing pigeons participate in sports competitions. The aim of the study was to analyze single nucleotide polymorphisms (SNPs) in the GSR and LRP8 genes in homing pigeons and to evaluate the potential impact of these genotypes on racing performance, as well as their structural consequences for the encoded proteins. The research included a total of 311 young individuals. DNA was extracted from the blood. Genotypes were determined by the ACRS-PCR test designed. Statistical analysis revealed that the c.606G > T polymorphism in LRP8 gene significantly influenced racing performance, was associated with race performance heterozygous GT pigeons achieving higher mean values of ace points (AP) than homozygous individuals. Therefore, the GT genotype may serve as a selection criterion in pigeon breeding. Further research is necessary to confirm the functionality of the GSR KB376299.1:62398C > T SNP in shaping the racing phenotype of pigeons.
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