Related Experiment Video
Updated: May 13, 2025
07:43
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
Published on: May 12, 2015
11.2K
Manifold functions of Mediator complex in neurodevelopmental disorders
Yi-Wei Li1, Si-Xin Tu1, Ze-Xuan Li1
1Laboratory Animal Center, Fudan University, Shanghai 200032, China.
Neurobiology of Disease
|April 17, 2025
Summary
Dysfunction in the Mediator complex, crucial for gene expression, is linked to neurodevelopmental disorders (NDDs). This review examines Mediator subunits and their genetic links to NDDs for better diagnostics and treatments.
Area of Science:
- Neuroscience
- Genetics
- Molecular Biology
Background:
- Neurodevelopmental disorders (NDDs) are diverse impairments affecting brain development and function.
- Genetic variants identified via next-generation sequencing implicate pathways in neuronal processes.
- The Mediator complex is vital for RNA polymerase II-dependent transcription and neuronal development.
Purpose of the Study:
- To review the structural and functional aspects of individual Mediator complex subunits.
- To explore the link between genetic abnormalities in the Mediator complex and NDD phenotypes.
- To guide the development of improved diagnostic tools and therapeutic interventions for NDDs.
Main Methods:
- Review of clinical case reports.
- Analysis of recent preclinical studies.
- Examination of genetic abnormalities in Mediator complex subunits.
Main Results:
- Growing evidence links Mediator complex dysfunction to NDD pathogenesis.
- Specific neurodevelopmental phenotypes are associated with genetic abnormalities in Mediator subunits.
- Transcriptional regulation plays a significant role in the etiology of NDDs.
Conclusions:
- Understanding Mediator subunit function is key to NDD research.
- Genetic insights into the Mediator complex can inform diagnostic and therapeutic strategies.
- This review advances knowledge on transcriptional regulation in NDDs.
Keywords:
Case reportGenome-wide association studyMediator complexNeurodevelopmental disordersTranscriptional regulationMore Related Videos
Related Concept Videos
01:31Neurotransmitters
728
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
728
01:32Assembly of Complex Microtubule Structures
1.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
1.8K
01:23Role of Neurotransmitters in Memory
318
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
318
01:28Human Genetics
473
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
473
01:30Attention-Deficit/Hyperactivity Disorder
26
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
26
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
277
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
277