[Treatment of essential hypertension (hypertensive disease) with verapamil and hydrochlorothiazide]

Area of Science:

• Cardiology
• Pharmacology

Context:

• Essential hypertension (WHO stages I and II) affects a significant patient population.
• Current treatment guidelines necessitate effective and well-tolerated antihypertensive therapies.

Purpose:

• To evaluate the efficacy and tolerability of Isoptin (verapamil hydrochloride) in combination with hydrochlorothiazide for essential hypertension.

Summary:

• Thirty-two patients received a phased treatment including placebo, hydrochlorothiazide alone, and a combination of Isoptin (80 mg) and hydrochlorothiazide (25 mg).
• Significant reductions in systolic and diastolic arterial pressure were observed with hydrochlorothiazide monotherapy compared to placebo.
• The addition of Isoptin resulted in further blood pressure reduction, with 15.6% experiencing mild adverse effects. No severe adverse events were noted.

Impact:

• Isoptin combined with hydrochlorothiazide (Esidrex) is an effective and well-tolerated treatment for essential hypertension.
• This combination therapy demonstrates no potentiation of adverse effects, expanding therapeutic options for managing hypertension.