Clinical Phenotype and Prognostic Significance of Frailty in Transthyretin Cardiac Amyloidosis
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View abstract on PubMed
Summary
This summary is machine-generated.Frailty is common in transthyretin cardiac amyloidosis (ATTR-CA), affecting over half of patients. Assessing frailty improves mortality risk prediction in ATTR-CA patients.
Area Of Science
- Cardiology
- Geriatrics
- Amyloidosis Research
Background
- Frailty prevalence and impact in transthyretin cardiac amyloidosis (ATTR-CA) are not well understood.
- ATTR-CA is a progressive disease affecting the heart.
Purpose Of The Study
- To determine the prevalence of frailty in a large ATTR-CA cohort.
- To identify factors associated with frailty.
- To assess the prognostic value of frailty for mortality.
Main Methods
- 880 ATTR-CA patients were assessed using the Clinical Frailty Scale (CFS).
- Frailty was analyzed continuously and categorically.
- Predictors and mortality associations were evaluated.
Main Results
- 57.1% of patients were frail (CFS ≥ 4).
- Older age, female sex, specific genetic variants, and advanced disease stage predicted frailty.
- Mortality risk increased significantly with higher frailty scores (log-rank P < 0.001).
Conclusions
- Frailty is highly prevalent in ATTR-CA.
- Frailty is an independent predictor of mortality in ATTR-CA.
- Integrating frailty assessment enhances prognostication, especially for short-term risk.
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