Related Experiment Video
Updated: Aug 17, 2026

Collection of Alfalfa Root Exudates to Study the Impact of Di(2-ethylhexyl) Phthalate on Metabolite Production
Published on: June 2, 2023
Excretion and metabolism of di(2-ethylhexyl)phthalate in man
Abstract:
Di-(2-ethylhexyl)phthalate (DEHP) taken orally by two volunteers (30 mg each) was excreted in the urine to the extent of 11 and 15% of dose. After enzymic hydrolysis the urinary metabolites (derivatives of mono (2-ethylhexyl)phthalate) were methylated and identified by g.l.c.-mass spectrometry (C.I.), and the quantitative distribution of conjugated and free metabolites determined. DEHP taken by the same volunteers over a period of four days at doses of 10 mg daily gave no evidence of accumulation; 15 and 25% of the total dose was recovered in the urine.
Related Concept Videos
Drug Metabolism: Phase II Reactions
Drug Elimination: Non-Renal Routes
Drug Elimination: Overview
Excretion refers to removing a drug from the body, either in its unchanged form or as its metabolites. Nonvolatile and polar drugs are primarily excreted through the kidneys, with other pathways including bile, sweat, saliva, and milk. Volatile drugs such as anesthetic gases are excreted via the...
Drug Excretion: Miscellaneous Routes
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Toxicity Testing in Animals

