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Related Experiment Video

Updated: May 21, 2025

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Carbon Ion Radiotherapy Reirradiation for Recurrent Malignancy: A Systematic Assessment.

H Ruan¹, C Zhang², S Chen³

¹Department of Radiation Oncology, Jiangxi Cancer Hospital, Jiangxi Cancer Center, 330029, Nanchang, Jiangxi Province, China; Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi 371-8511, Gunma, Japan.

Clinical Oncology (Royal College of Radiologists (Great Britain))

|April 17, 2025

Summary

Carbon ion reirradiation shows promise for treating recurrent cancers, offering favorable outcomes and low toxicity across various sites. This advanced radiation therapy is a potentially safe and effective option for challenging locoregional malignancies.

Keywords:

Carbon ion Clinical outcomes Locoregional recurrence Malignancy Reirradiation Toxicities

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Published on: March 11, 2021

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Last Updated: May 21, 2025

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

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Published on: February 12, 2017

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

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Published on: May 8, 2018

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

Oncology
Radiation Oncology
Medical Physics

Background:

Reirradiation is a significant clinical challenge in managing recurrent malignancies.
Modern radiation therapy advances have improved outcomes, but reirradiation remains complex.
Carbon ion radiotherapy offers potential advantages in dose distribution and radiobiology.

Purpose of the Study:

To systematically review clinical outcomes of carbon ion reirradiation for locoregional recurrent malignancies.
To evaluate the efficacy and safety of carbon ion reirradiation across diverse cancer types.
To assess the impact of concurrent chemotherapy on toxicity.

Main Methods:

Systematic review of 27 original studies.
Inclusion of studies on central nervous system, lung, head and neck, pancreas, liver, rectum, and gynecological sites.
Analysis of clinical outcomes including survival rates and toxicity.

Main Results:

Carbon ion reirradiation demonstrated favorable clinical outcomes with low high-grade toxicities.
Specific survival rates reported for nasopharyngeal carcinoma, glioblastoma, lung, and pancreatic cancers.
Concurrent chemotherapy showed minimal additive high-grade toxicities.

Conclusions:

Carbon ion reirradiation is a potentially safe and effective modality for locoregional recurrent malignancies.
Further research is needed due to limited data.
Carbon ion therapy represents a promising advancement in radiation oncology for recurrent disease.