[Simulation Study of Myocardial Tissue Ablation Effects Using Flower Petal-Structured Electrodes in Pulsed Ablation].

Area of Science:

• Biomedical Engineering
• Electrophysiology
• Medical Devices

Context:

• Atrial fibrillation treatment often involves thermal ablation, carrying risks of collateral damage.
• Pulsed field ablation (PFA) offers a non-thermal alternative, but electrode design is crucial for efficacy.
• Flower petal-structured electrodes are explored for improved PFA performance.

Purpose:

• To evaluate flower petal-structured electrodes for myocardial tissue ablation using pulsed field ablation (PFA).
• To investigate the impact of voltage and electrode-tissue distance on ablation characteristics.
• To validate simulation findings with in vitro experiments.

Summary:

• Simulations and in vitro experiments using potato tissue assessed flower petal electrodes in PFA.
• Increased voltage correlated with greater ablation depth; 2500V achieved 4mm transmural ablation.
• PFA demonstrated non-thermal characteristics with minimal temperature rise and continuous ablation areas.

Impact:

• PFA with novel electrodes shows potential for efficient myocardial ablation with reduced complications.
• This technology presents a new pathway for treating atrial fibrillation.
• The non-thermal nature of PFA minimizes risks associated with traditional ablation methods.