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The prognostic value of CXCR4 PET/CT imaging in unilateral primary aldosteronism patients after adrenalectomy

  • 0Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
Ejnmmi Research +

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April 17, 2025

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April 17, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

CXCR4 PET/CT imaging, using the lesional to contralateral adrenal ratio (LCR), predicts blood pressure recovery after primary aldosteronism surgery. An LCR over 3.240 indicates better outcomes.

Area Of Science

  • Endocrinology
  • Nuclear Medicine
  • Radiology

Background

  • CXCR4 PET/CT imaging aids in diagnosing and subtyping primary aldosteronism (PA).
  • The prognostic value of CXCR4 PET/CT for predicting postoperative blood pressure recovery in PA requires further investigation.

Purpose Of The Study

  • To evaluate the prognostic value of CXCR4 PET/CT imaging in predicting blood pressure recovery after adrenalectomy in patients with PA.
  • To determine if the lesional SUVmax to contralateral adrenal tissue SUVmean ratio (LCR) can predict clinical success post-surgery.

Main Methods

  • Retrospective analysis of patients with PA who underwent CXCR4 PET/CT imaging and adrenalectomy.
  • Calculation of the lesional to contralateral adrenal tissue SUVmean ratio (LCR).
  • Statistical analysis to assess LCR as an independent predictor of clinical success at 3 and 6 months post-surgery.

Main Results

  • LCR was identified as an independent predictor of clinical success at 3 and 6 months post-surgery (AUC 0.894 and 0.832, respectively).
  • A high LCR group (cut-off 3.240) showed elevated CXCR4 and CYP11B2 expression, higher PAC levels, and a greater probability of complete clinical success.
  • LCR correlated with lateralization and contralateral suppression indices.

Conclusions

  • LCR is a reliable independent predictor of postoperative blood pressure recovery in PA patients.
  • Patients with an LCR > 3.240 may experience greater benefits from adrenalectomy.
  • Increased utilization of CXCR4 PET/CT is recommended for PA patient management.

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