Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.3K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

833
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
833
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

1.7K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
1.7K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

10.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.7K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

216
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
216

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Misclassification of type 1 diabetes as type 2 diabetes in adults: practical guidance for screening and diagnosis for primary care providers.

Postgraduate medicine·2026
Same author

A Post-Hoc Analysis of Depressive Disorders in Patients with Type 2 Diabetes.

Healthcare (Basel, Switzerland)·2025
Same author

Double Diabetes: A Clinical Challenge.

Clinical diabetes : a publication of the American Diabetes Association·2025
Same author

The quality of data-driven hypotheses generated by inexperienced clinical researchers: A case study.

medRxiv : the preprint server for health sciences·2024
Same author

Type 2 Diabetes and Chronic Kidney Disease: An Opportunity for Pharmacists to Improve Outcomes.

Journal of clinical medicine·2024
Same author

Guideline-based management of metabolic dysfunction-associated steatotic liver disease in the primary care setting.

Postgraduate medicine·2024

Related Experiment Video

Updated: May 20, 2025

A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination
12:33

A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination

Published on: June 25, 2014

65.1K

Beta-cell preservation in T2DM using a pathophysiologic approach.

Konstantino Papatheodorou1, Jay H Shubrook2

  • 1Student Services, Touro University, California, College of Osteopathic Medicine, Vallejo, CA, USA.

Postgraduate Medicine
|April 18, 2025
PubMed
Summary
This summary is machine-generated.

Type 2 diabetes management needs a proactive, pathophysiologic approach focusing on beta-cell preservation. This strategy improves treatment success and reduces complications for the growing number of patients.

Keywords:
Type 2 diabetesbeta-cell dysfunctionbeta-cell preservationinsulin resistancepathophysiologyremission

More Related Videos

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

1.7K
Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
09:31

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

7.2K

Related Experiment Videos

Last Updated: May 20, 2025

A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination
12:33

A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination

Published on: June 25, 2014

65.1K
Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

1.7K
Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
09:31

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

7.2K

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Research

Background:

  • Rising global rates of type 2 diabetes and obesity present significant public health challenges.
  • Current type 2 diabetes treatments often fall short of therapeutic goals for many individuals.
  • Understanding the underlying pathophysiology is crucial for effective disease management.

Purpose of the Study:

  • To review the evolving understanding of type 2 diabetes pathophysiology.
  • To highlight the critical role of beta-cell health in diabetes progression.
  • To introduce a pathophysiologic approach emphasizing beta-cell preservation for improved treatment outcomes.

Main Methods:

  • Comprehensive narrative review of existing literature.
  • Compilation of clinical data and evidence-based medicine.
  • Inclusion of experimental research findings.

Main Results:

  • The article details the progressive understanding of diabetes pathophysiology.
  • It establishes a clear link between overall illness and pancreatic beta-cell function.
  • It outlines a pathophysiologic approach centered on preserving beta-cell function.

Conclusions:

  • A proactive, pathophysiologic approach to type 2 diabetes is essential for achieving therapeutic goals.
  • Focusing on beta-cell preservation can lead to better patient outcomes and fewer complications.
  • This review synthesizes current knowledge to support a more effective treatment strategy.