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Related Experiment Video

Updated: May 11, 2025

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer

Published on: December 26, 2016

Retrospective Case-Cohort Study on Risk Factors for Developing Distant Metastases in Women With Breast Cancer.

Serena Bertozzi¹, Ambrogio Pietro Londero^2,3, Giovanni Vendramelli¹

¹Breast Unit, University Hospital of Udine, ASUFC, Udine, Italy.

Cancer Medicine

|April 18, 2025

Summary

Identifying breast cancer metastasis risk factors is crucial. Lobular carcinoma, triple-negative subtype, high grade, and larger tumor size increase metastasis risk, while progesterone receptor expression is protective.

Keywords:

breast cancer metastasis distant recurrence prediction machine learning personalized treatment progesterone receptor risk factors tumor subtype

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Last Updated: May 11, 2025

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Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior

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Published on: June 13, 2016

Area of Science:

Oncology
Cancer Research
Medical Statistics

Background:

Metastasis is a primary driver of breast cancer mortality.
Understanding risk factors is key for early intervention and improved patient outcomes.

Purpose of the Study:

To identify risk factors for distant metastases in breast cancer patients.
To analyze survival rates in relation to metastasis development.
To explore the link between local recurrences and distant metastases.

Main Methods:

Retrospective case-cohort study of women with breast cancer (2001-2015).
Comparison of patients who developed distant metastases with those who did not.
Analysis of patient characteristics, tumor biology, and treatment data.

Main Results:

Significant risk factors for metastasis include lobular invasive carcinoma, triple-negative subtype, high tumor grade, larger tumor size, lymph node involvement, and loco-regional recurrence.
Progesterone receptor (PR) expression demonstrated a protective effect (OR 0.52).
20-year overall survival was significantly lower for patients with metastasis (23.62%) compared to controls (99.23%).

Conclusions:

Lobular invasive carcinoma, specific subtypes, high grade, larger tumor size, lymph node involvement, and loco-regional recurrence are confirmed risk factors for distant metastasis.
Progesterone receptor expression is a protective factor against metastasis.
Machine learning shows potential for personalized metastasis risk assessment in breast cancer.