Related Experiment Video

Updated: May 11, 2025

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
10:35

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo

Published on: April 6, 2022

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Estimated glucose disposal rate mediates the association between Life's Crucial 9 and congestive heart failure: a

Liping Wang1, Yaying Xu2, Lele Chen3

  • 1Department of Cardiovascular, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.

Frontiers in Endocrinology
|April 18, 2025
PubMed

Insights

Higher Life's Crucial 9 (LC9) scores and estimated glucose disposal rate (eGDR) are linked to lower congestive heart failure (CHF) risk. eGDR significantly mediates this association, suggesting improved insulin resistance contributes to cardiovascular health.

Area of Science:

  • Cardiology
  • Metabolic Health
  • Public Health

Background:

  • Life's Crucial 9 (LC9) is an emerging cardiovascular health (CVH) indicator.
  • Estimated glucose disposal rate (eGDR) reflects insulin resistance (IR).
  • The relationship between LC9, eGDR, and congestive heart failure (CHF) was previously unestablished.

Purpose of the Study:

  • To investigate the associations between LC9, eGDR, and CHF prevalence.
  • To explore the mediating role of eGDR in the LC9-CHF relationship.

Main Methods:

  • Cross-sectional analysis of 22,699 US adults from NHANES (2005-2018).
  • Weighted linear and logistic regression models were used.
  • Mediation analysis assessed the indirect effect of LC9 on CHF via eGDR.

Main Results:

  • LC9 was positively associated with eGDR (β: 1.11, P < 0.0001).
  • Both LC9 (OR: 0.76, P < 0.001) and eGDR (OR: 0.81, P < 0.0001) were negatively associated with CHF prevalence.
  • eGDR mediated 66% of the association between LC9 and CHF.

Conclusions:

  • Higher LC9 and eGDR are associated with reduced CHF risk.
  • eGDR plays a significant mediating role, suggesting improved insulin sensitivity is key.
  • These findings highlight the potential of LC9 and eGDR in managing cardiovascular health and preventing CHF.
Abstract

Keywords:
Congestive Heart Failure (CHF)Life’s Crucial 9 (LC9)NHANEScross-sectional studyestimated glucose disposal rate (eGDR)mediation analysis

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