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Plasmonic wearable adhesive patch for a SERS-based sweat sensor.

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This summary is machine-generated.

Researchers developed a wearable patch for molecular fingerprinting of body fluids. This surface-enhanced Raman scattering (SERS) sensor accurately detects urea and lactate in sweat, advancing personalized healthcare devices.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Materials Science

Background:

  • Wearable sensors for molecular fingerprinting of body fluids are crucial for personalized healthcare.
  • Existing technologies face challenges in direct skin application and nanoparticle exposure.

Purpose of the Study:

  • To design and develop a novel two-layer paper-based wearable patch for sensitive and selective detection of sweat components.
  • To optimize the patch for skin adhesion and ensure safe integration of nanoparticles and laser excitation.

Main Methods:

  • A two-layer paper substrate was fabricated: one layer for skin adhesion (polydimethylsiloxane and oleic acid) and another for Raman signal enhancement (in situ reduced nanoparticles).
  • The adhesive mixture's volume ratio was optimized for maximum adhesion.
  • Surface-enhanced Raman spectroscopy (SERS) was employed for molecular fingerprinting of sweat components.

Main Results:

  • The plasmonic paper achieved excellent limits of detection for urea (55.9 μM) and lactate (47.8 μM).
  • Multiplexed detection of urea and lactate directly from sweat was successfully demonstrated using the skin-adhesive patch.
  • The patch design prevented direct skin exposure to nanoparticles and the excitation laser.

Conclusions:

  • The developed SERS patch is a promising wearable healthcare sensor for molecular fingerprinting of body fluids.
  • This technology opens new possibilities for wearable personalized healthcare devices.