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Updated: May 11, 2025

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
Published on: April 22, 2015
Evaluating the impact of essential amino acid-rich nutrition intervention on children with autism spectrum disorder:
Jayashree R1, Gayathri G1, Udayakumar N2
1Department of Clinical Nutrition, Sri Ramachandra Faculty of Allied Health sciences, Sri Ramachandra Institute Higher Education and Research, Chennai, India.
Background:
Emerging evidence highlights the role of essential amino acids in brain function and behavior modulation, with deficiencies observed in children with autism. Amino acid supplementation appears to be effective in the autism management. This study aims to assess the effect of plant based amino acid intervention on plasma amino acid profile and behavior aspects in children with autism spectrum disorder.
Methods:
•The study involves parallel, randomized controlled trial that will include 68 children (age 3-6 years) with mild to moderate ASD. Children will be randomly assigned (1:1) to intervention group receiving nutritional intervention or a control group continuing standard care.•The intervention will be carried out over 16 weeks, with a dosage based on the child's weight and dietary needs.•Primary outcomes include changes in plasma amino acid concentrations Secondary outcomes include changes in Childhood Autism Rating Scale (CARS) and Autism Treatment Evaluation Checklist (ATEC) scores which would be measured pre- and post-intervention.
Results:
Plasma amino acid levels and behavioral assessments will be compared between the groups to determine the effectiveness of the nutritional intervention in improving symptoms.
Conclusion:
This trial seeks to establish a sustainable, non-pharmacological approach to managing autism symptoms. Findings would contribute to autism dietary management strategies and the role of essential amino acids in neurodevelopmental health.
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