Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The cocktail method: influence of microbubble shell homogeneity on acoustic behavior and stability.

Soft matter·2026

Same author

Hexavalent Chromium Exposure Disrupts Cardiac Development in Chicken Embryos Through Oxidative Stress and Activation of TGFβ1/COL3A1 Pathway in Chick Embryos.

Cardiovascular toxicology·2026

Same author

Bird diversity and health status of bioindicator species (Coturnix coturnix, Horsfield, 1821) in Egypt's Manzala Lagoon: seasonal resilience monitoring.

Environmental monitoring and assessment·2026

Same author

Post-pubertal Susceptibility to Cadmium-Induced Cardiac Injury: Role of Metallothionein, Antioxidant Defense, and Endocrine Modulation.

Cardiovascular toxicology·2025

Same author

Immunomodulatory intraperitoneal chemotherapy with DACHPt-loaded biomaterial nanoparticles in colorectal carcinomatosis.

Pharmacological research·2025

Same author

Functional and Evolutionary Role of Reproductive Hormonal Dysregulation Following Dietary Exposure to Singed Meat.

International journal of molecular sciences·2025

Search research articles

Related Experiment Video

Updated: May 11, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Cyclic jetting enables microbubble-mediated drug delivery.

Marco Cattaneo¹, Giulia Guerriero¹, Gazendra Shakya¹

¹Institute of Fluid Dynamics, ETH Zürich, Zürich, Switzerland.

|April 18, 2025

Summary

Ultrasound-responsive microbubbles puncture cell membranes via stable cyclic microjets, enabling targeted drug delivery. This mechanism, driven by shape instabilities, enhances cellular uptake at mild pressures.

Keywords:

Biophysics Fluid dynamics

More Related Videos

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Published on: February 21, 2014

Studying Cavitation Enhanced Therapy

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

Related Experiment Videos

Last Updated: May 11, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

Published on: June 12, 2021

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Published on: February 21, 2014

Studying Cavitation Enhanced Therapy

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

Area of Science:

Biomedical Engineering
Acoustic Physics
Drug Delivery Systems

Background:

Targeted therapies face challenges overcoming biological barriers like the blood-brain barrier.
Stimuli-responsive microagents, such as ultrasound-responsive microbubbles, show promise for improved therapeutic efficacy.
The precise mechanism of drug absorption mediated by microbubbles remains unclear.

Purpose of the Study:

To elucidate the mechanism of drug absorption induced by ultrasound-driven microbubbles.
To investigate the role of microbubble dynamics in cellular drug uptake.
To establish criteria for the effective and safe application of microbubble-mediated drug delivery.

Main Methods:

Experimental observation of ultrasound-driven single microbubble interactions with cell membranes.
Development and application of theoretical models to simulate bubble and cell dynamics.
Analysis of microjet formation, bubble radial expansion, and cellular permeation.

Main Results:

Ultrasound-driven microbubbles induce drug uptake by puncturing cell membranes via stable cyclic microjets.
Cyclic jets originate from shape instabilities, distinct from classical inertial jets, forming at pressures below 100 kPa.
A specific threshold for bubble radial expansion is identified for microjet formation and cellular permeation, with microjetting stress significantly outperforming other mechanisms.

Conclusions:

This study clarifies the physics of microbubble-mediated targeted drug delivery.
Stable cyclic microjets are the primary mechanism for ultrasound-induced cellular drug uptake.
The findings provide essential criteria for optimizing the safety and efficacy of this therapeutic approach.