Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

958
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
958
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

538
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
538
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

826
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
826
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

75
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
75
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

35
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
35
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

19
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
19

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of hospital process reengineering on door-to-needle time for intravenous thrombolysis in acute ischemic stroke (PROMISE-CHINA): a multicenter prospective pre-post quasi-experimental study.

Frontiers in neurology·2026
Same author

Rehabilitation paired with vagus nerve stimulation for motor function of chronic ischemic stroke patients in China: Study protocol of a multicenter randomized controlled trial (Repair Study).

Neuroprotection (Chichester, England)·2026
Same author

Thalamic glutamatergic neurons regulate seizure onset and generalization in temporal lobe epilepsy.

Cell reports·2026
Same author

Biodegradable microplastics-induced free-living nitrogen fixation enhancement and diazotrophic community differentiation in soils.

Journal of environmental management·2026
Same author

Clinical characteristics analysis of stroke patients with lower extremity deep venous thrombosis.

Frontiers in neurology·2026
Same author

Safety and Feasibility of YC-6 in Patients With Large Hemispheric Infarction: A Randomized Clinical Trial.

Journal of the American Heart Association·2025

Related Experiment Video

Updated: May 11, 2025

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing
01:00

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

Published on: December 1, 2023

425

Very Late-Onset Myasthenia Gravis Presenting With Dysphagia and Gradual Decrease in Laryngeal Elevation During

Yujuan Han1, Dawei Zang2, Xiaoping Kang1

  • 1Tiantan Xiaotangshan Rehabilitation Center Beijing Xiaotangshan Hospital Beijing China.

Clinical Case Reports
|April 18, 2025
PubMed
Summary

Very late-onset myasthenia gravis (VLOMG) can present as isolated swallowing difficulties in individuals over 65. Early recognition of symptoms like dysphagia and reduced laryngeal elevation is crucial for timely diagnosis and management.

Keywords:
dysphagiaelderlymyasthenic crisisupper gastrointestinal radiographyvery late‐onset myasthenia gravis

More Related Videos

Robotic Myotomy and Partial Fundoplication for Achalasia
11:19

Robotic Myotomy and Partial Fundoplication for Achalasia

Published on: August 11, 2023

1.4K
An Implantable System For Chronic In Vivo Electromyography
09:52

An Implantable System For Chronic In Vivo Electromyography

Published on: April 21, 2020

10.6K

Related Experiment Videos

Last Updated: May 11, 2025

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing
01:00

Minimally Invasive Murine Laryngoscopy for Close-Up Imaging of Laryngeal Motion During Breathing and Swallowing

Published on: December 1, 2023

425
Robotic Myotomy and Partial Fundoplication for Achalasia
11:19

Robotic Myotomy and Partial Fundoplication for Achalasia

Published on: August 11, 2023

1.4K
An Implantable System For Chronic In Vivo Electromyography
09:52

An Implantable System For Chronic In Vivo Electromyography

Published on: April 21, 2020

10.6K

Area of Science:

  • Neurology
  • Geriatrics
  • Gastroenterology

Background:

  • Very late-onset myasthenia gravis (VLOMG) is a rare subtype of myasthenia gravis (MG) characterized by onset after age 65.
  • Dysphagia and dysarthria are common presenting symptoms in MG, but can be isolated in VLOMG.

Purpose of the Study:

  • To highlight the importance of considering VLOMG in elderly patients presenting with specific swallowing abnormalities.
  • To describe a case of VLOMG presenting with isolated dysphagia.

Main Methods:

  • Case report of a 72-year-old patient with dysphagia.
  • Diagnostic evaluation included upper gastrointestinal radiography.
  • Serological testing for anti-acetylcholine receptor (anti-AChR) antibodies.

Main Results:

  • Upper GI radiography showed delayed pharyngeal swallowing initiation and inadequate upper esophageal sphincter opening.
  • A gradual decrease in laryngeal elevation during swallowing was observed, suggestive of MG.
  • The patient tested positive for anti-AChR antibodies and experienced type I respiratory failure requiring ventilatory support.

Conclusions:

  • VLOMG should be suspected in patients over 65 with sudden, isolated dysphagia or dysarthria.
  • Characteristic radiographic findings, such as reduced laryngeal elevation, can aid in diagnosis.
  • Prompt recognition and management are essential for improving patient outcomes.