Diagnostic and theranostic opportunities in Neuro-oncology

Theranostics, the interlinking of diagnostic and therapeutic procedures, can be particularly valuable in neuro-oncology, addressing the challenges posed by the blood-brain and brain-tumor barriers. While it is traditionally associated with nuclear medicine, advances in MR imaging techniques have opened new theranostic frontiers. This review covers the present challenges in neuro-oncology and how these could be overcome utilizing radioligand-based molecular radiotherapy as well as how label-free theranostics employing methods such as chemical exchange saturation transfer (CEST) and MR spectroscopy could advance the field.