Idiopathic sialadenosis mimicking neoplasms: Clinical and histopathological considerations

Soft tissue lesions involving the posterior palate region are unusual cases, especially among children. In such scenarios, it is essential to arrive at an accurate and conclusive diagnosis and also rule out malignancies. Several allergic diseases resulting in sialadenitis have been identified which include Kimura's disease, eosinophilic sialodochitis, and IgG4-related sialadenitis. In the current case report, we have described the unique histopathological findings of a rare lesion involving the posterior palate linked to elevated levels of serum IgE. Primary hyper-IgE-related salivary gland disease has been described as the homogenous enlargement of multiple salivary glands associated with elevated serum IgE levels. They may also be associated with allergic anaphylaxis or autoimmune dysfunction. Literature has revealed similar lesions involving the major glands; however, the current study describes a rare and de-novo finding in which the minor glands of the palate are involved along with a review of literature of various cases of idiopathic sialadenosis.