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Updated: May 11, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Synthesis of Functionalized Benzocycloheptene Analogs
Shivangi Kharbanda1, Osaid Alkhamayseh1, Georgia Eastham1
1Department of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, United States.
Abstract:
The benzocycloheptene core is structurally important motif that appears within a wide array of natural products, and benzocycloheptene has recently been demonstrated to undergo [3+2] photo-sensitized cycloaddition reactions. Thus, there is a need for efficient synthetic protocols to access this motif. Herein, we provide efficient strategies to achieve highly functionalized benzocycloheptene derivatives starting from commercially available 1-benzosuberone and 1-tetralone. We anticipate that these benzocycloheptene compounds will serve as excellent precursors for a diverse array of chemical reactions.
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