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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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Updated: May 11, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
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Benign non-immune cells in tumor microenvironment.

Shaowen Liu1, Chunhui Liu2,3, Yuan He1

  • 1State Key Laboratory of Natural Medicines, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.

Frontiers in Immunology
|April 18, 2025
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Summary

Benign non-immune cells in the tumor microenvironment (TME) significantly influence cancer progression. Understanding their diverse roles across tumor types is key to developing targeted therapies.

Keywords:
adipocytesbenign non-immune cellscancer-associated fibroblastsendothelial cellspericytesschwann cellstumor heterogeneitytumor microenvironment

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Area of Science:

  • Oncology
  • Cancer Biology
  • Tumor Microenvironment Research

Background:

  • The tumor microenvironment (TME) is a complex ecosystem crucial for tumor development.
  • Benign non-immune cells, such as cancer-associated fibroblasts (CAFs) and endothelial cells (ECs), are key components of the TME.
  • These cells interact with tumor and immune cells, influencing tumor progression.

Purpose of the Study:

  • To review the diverse roles of benign non-immune cells within the TME.
  • To highlight how these roles vary across different cancer types based on tumor heterogeneity.
  • To underscore the importance of understanding these cells for novel cancer therapy development.

Main Methods:

  • Literature review of studies on benign non-immune cells in various cancer types.
  • Analysis of interactions between benign non-immune cells, tumor cells, and immune cells within the TME.
  • Examination of signaling pathways and factors involved in tumor promotion by these cells.

Main Results:

  • Benign non-immune cells play critical roles in tumor development and progression.
  • Their functions and impact differ significantly depending on the specific cancer type and tumor heterogeneity.
  • Multiple signaling pathways are implicated in tumor-promoting mechanisms mediated by these cells.

Conclusions:

  • Targeting benign non-immune cells in the TME offers a promising strategy for novel cancer therapies.
  • A deeper understanding of tumor heterogeneity is essential for effective therapeutic targeting.
  • Further research into the specific roles of these cells across diverse cancers is warranted.