The 4977 Bp Deletion of Mitochondrial DNA as a Potential Trait Marker for Major Depressive Disorder
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Updated: May 11, 2025
Genotyping Single Nucleotide Polymorphisms in the Mitochondrial Genome by Pyrosequencing
Published on: February 10, 2023
Ying He1, Xinbo Yang1, Zongchang Li1
1Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People's Republic of China.
Background:
Major depressive disorder (MDD) is significantly influenced by genetic factors. The present study aims to examine the potential correlation between the 4977 bp deletion of mitochondrial DNA (mtDNA) and MDD.
Methods:
The 4977 bp deletion of mtDNA was detected in the peripheral blood of 253 MDD patients and 257 healthy controls, with depression assessed by the Hamilton Depression Rating scale and functioning by the Global Assessment of Function Scale.
Results:
MDD patients had a higher incidence of the 4977 bp deletion, unaffected by demographic or clinical factors.
Conclusion:
The 4977 bp deletion may be a trait marker for MDD.
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