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Risk factors for incident peripartum mental illness in multiple sclerosis
Ruth Ann Marrie1, James M Bolton2, Vicki Ling3
1Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|April 18, 2025
Summary
Mothers with multiple sclerosis (MS) experiencing higher community deprivation or MS disability face increased risks of peripartum mental illness. Early identification can guide crucial mental health support.
Area of Science:
- Reproductive Health
- Neurology
- Mental Health Research
Background:
- Mothers with multiple sclerosis (MS) exhibit higher rates of peripartum mental illness compared to the general population.
- Peripartum mental illness encompasses conditions like depression, anxiety, and bipolar disorder during pregnancy and the postpartum period.
Purpose of the Study:
- To identify risk factors for peripartum mental illness in mothers diagnosed with multiple sclerosis.
- To inform clinical practice for identifying at-risk individuals and providing timely support.
Main Methods:
- Utilized linked population-based administrative data from Ontario, Canada (2002-2019).
- Included 1745 mothers with MS and live births.
- Employed multivariable Poisson regression to analyze associations between sociodemographic and clinical factors and mental illness incidence.
Main Results:
- Higher area-level deprivation (e.g., lack of community cohesion) correlated with increased peripartum depression and anxiety.
- Elevated multiple sclerosis disability levels were linked to higher rates of peripartum depression.
Conclusions:
- Area-level deprivation and MS disability are significant risk factors for peripartum mental illness in mothers with MS.
- Findings support targeted screening and intervention strategies for vulnerable populations.
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