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Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

148
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

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Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
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Adaptive brain stimulation 2.0 for Parkinsonian gait.

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A systematic review exploring the safety of deep brain stimulation at MRI field strengths beyond conventional field strengths: Opening the door to new imaging tools for neuromodulation.

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Related Experiment Video

Updated: May 11, 2025

Author Spotlight: Automated Deep Brain Stimulation for Parkinson's Disease - Exploring the Possibilities and Challenges of Home Monitoring
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Stimulation-Induced Dyskinesia in STN DBS Patients.

Carolina Candeias da Silva1,2, Wilson K W Fung1,3, Duha M Al-Shorafat1,4

  • 1Edmond J. Safra Program in Parkinson's Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.

Movement Disorders Clinical Practice
|April 18, 2025
PubMed
Summary

Stimulation-induced dyskinesia (SID) is a common side effect of subthalamic deep brain stimulation (STN DBS) for Parkinson's disease (PD). Management strategies are often required due to its potential persistence.

Keywords:
Parkinson's diseasedeep brain stimulationdyskinesiasstimulation‐induced dyskinesias

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Area of Science:

  • Neurology
  • Neurosurgery
  • Movement Disorders

Background:

  • Stimulation-induced dyskinesia (SID) is a poorly understood complication of subthalamic deep brain stimulation (STN DBS) for Parkinson's disease (PD).
  • SID can cause significant distress for patients undergoing STN DBS for PD.

Purpose of the Study:

  • To characterize the features of SID in Parkinson's disease patients receiving STN DBS.
  • To identify factors associated with SID occurrence.
  • To describe management strategies for SID.

Main Methods:

  • Retrospective analysis of 86 patients with Parkinson's disease who underwent STN DBS.
  • Correlation of clinical features and volume of tissue activated (VTA) with SID.
  • Review of management strategies employed for SID.

Main Results:

  • SID occurred in 32.6% of patients, persisting for up to 6 months in 7.0%.
  • VTA overlap with the right motor subthalamic nucleus was significantly associated with SID (P < 0.02).
  • Dopaminergic drug weaning and reduced DBS amplitude were common management strategies.

Conclusions:

  • SID is a frequent complication of STN DBS in Parkinson's disease patients.
  • SID can be persistent and necessitate specific postoperative management.
  • Understanding VTA and clinical features aids in managing SID.